About our group
Our mission is to identify and validate key biological interactions implicated in human pathologies that could be targeted in therapeutic intervention. With this goal in mind we focus on detailed understanding of molecular mechanisms of various biological processes using the means of integrative structural biology. We use structural knowledge for understanding and also modulation of biological roles of proteins and protein-protein complexes. We foster our own research projects and actively share our expertise through a number of collaborations with the scientific community mainly but not exclusively at IOCB.

Publications
All publications
Structural insight into DNA recognition by bacterial transcriptional regulators of the SorC/DeoR family
Acta Crystallographica Section D: Structural Biology 77 (11): 1411-1424 (2021)
A ubiquitous disordered protein interaction module orchestrates transcription elongation
Science 374 (6571): 1113-1121 (2021)
Crystal structure of native β‐N‐acetylhexosaminidase isolated from Aspergillus oryzae sheds light onto its substrate specificity, high stability, and regulation by propeptide
FEBS Journal 285 (3): 580-598 (2018)
Molecular Mechanism of LEDGF/p75 Dimerization
Structure 28 (12): 1288-1299 (2020)
Identification of specific carbonic anhydrase inhibitors via in situ click chemistry, phage-display and synthetic peptide libraries: comparison of the methods and structural study
RSC Medicinal Chemistry 1 (14): 144-153 (2023)
Affinity switching of the LEDGF/p75 IBD interactome is governed by kinase-dependent phosphorylation
Proceedings of the National Academy of Sciences of the United States of America 115 (30): E7053-E7062 (2018)