Structural Biology | Pavlína Maloy Řezáčová Group

About our group

Our mission is to identify and validate key biological interactions implicated in human pathologies that could be targeted in therapeutic intervention. With this goal in mind we focus on detailed understanding of molecular mechanisms of various biological processes using the means of integrative structural biology. We use structural knowledge for understanding and also modulation of biological roles of proteins and protein-protein complexes. We foster our own research projects and actively share our expertise through a number of collaborations with the scientific community mainly but not exclusively at IOCB.

Structural insight into DNA recognition by bacterial transcriptional regulators of the SorC/DeoR family

M. Šoltysová I. Sieglová M. Fábry J. Brynda J. Škerlová P. Řezáčová

Acta Crystallographica Section D: Structural Biology 77 (11): 1411-1424 (2021)

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A ubiquitous disordered protein interaction module orchestrates transcription elongation

K. Čermáková J. Demeulemeester V. Lux M. Nedomová S. R. Goldman E. A. Smith P. Srb R. Hexnerová M. Fábry M. Mádlíková M. Hořejší J. De Rijck Z. Debyser K. Adelman H. C. Hodges V. Veverka

Science 374 (6571): 1113-1121 (2021)

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Crystal structure of native β‐N‐acetylhexosaminidase isolated from Aspergillus oryzae sheds light onto its substrate specificity, high stability, and regulation by propeptide

J. Škerlová J. Bláha P. Pachl K. Hofbauerová Z. Kukačka P. Man P. Pompach P. Novák Z. Otwinowski J. Brynda O. Vaněk P. Řezáčová

FEBS Journal 285 (3): 580-598 (2018)

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Molecular Mechanism of LEDGF/p75 Dimerization

V. Lux T. Brouns K. Čermáková P. Srb M. Fábry M. Mádlíková M. Hořejší Z. Kukačka P. Novák M. Kugler J. Brynda J. DeRijck F. Christ Z. Debyser V. Veverka

Structure 28 (12): 1288-1299 (2020)

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Identification of specific carbonic anhydrase inhibitors via in situ click chemistry, phage-display and synthetic peptide libraries: comparison of the methods and structural study

M. Kugler M. Hadzima R. Dzijak R. Rampmaier P. Srb L. Vrzal Z. Voburka P. Majer P. Řezáčová M. Vrábel

RSC Medicinal Chemistry 1 (14): 144-153 (2023)

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Affinity switching of the LEDGF/p75 IBD interactome is governed by kinase-dependent phosphorylation

S. Sharma K. Čermáková J. De Rijck J. Demeulemeester M. Fábry S. El Ashkar S. Van Belle M. Lepšík P. Těšina V. Duchoslav P. Novák M. Hubálek P. Srb F. Christ P. Řezáčová H. C. Hodges Z. Debyser V. Veverka

Proceedings of the National Academy of Sciences of the United States of America 115 (30): E7053-E7062 (2018)

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