Structural Biology | Pavlína Maloy Řezáčová Group

About our group

Our mission is to identify and validate key biological interactions implicated in human pathologies that could be targeted in therapeutic intervention. With this goal in mind we focus on detailed understanding of molecular mechanisms of various biological processes using the means of integrative structural biology. We use structural knowledge for understanding and also modulation of biological roles of proteins and protein-protein complexes. We foster our own research projects and actively share our expertise through a number of collaborations with the scientific community mainly but not exclusively at IOCB.

Structural characterization of two prototypical repressors of SorC family reveals tetrameric assemblies on DNA and mechanism of function

M. Šoltysová J. Škerlová P. Pachl K. Škubník M. Fábry I. Sieglová M. Farolfi I. Grishkovskaya M. Babiak J. Nováček L. Krásný P. Řezáčová

Nucleic Acids Research 2024: Early View

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Multivalency of nucleosome recognition by LEDGF

E. Koutná V. Lux T. Kouba J. Škerlová J. Nováček P. Srb R. Hexnerová H. Šváchová Z. Kukačka P. Novák M. Fábry S. Poepsel V. Veverka

Nucleic Acids Research 51 (18): 10011–10025 (2023)

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Design, Synthesis, Biological Evaluation, and Crystallographic Study of Novel Purine Nucleoside Phosphorylase Inhibitors

J. Skácel S. Đukić O. Baszczyňski F. Kalčic T. Bílek K. Chalupský J. Kozák A. Dvořáková E. Tloušťová Z. Kráľová M. Šmídková J. Voldřich M. Rumlová P. Pachl J. Brynda T. Vučková M. Fábry J. Snášel I. Pichová P. Řezáčová H. Mertlíková-Kaiserová Z. Janeba

Journal of Medicinal Chemistry 66 (10): 6652–6681 (2023)

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A ubiquitous disordered protein interaction module orchestrates transcription elongation

K. Čermáková J. Demeulemeester V. Lux M. Nedomová S. R. Goldman E. A. Smith P. Srb R. Hexnerová M. Fábry M. Mádlíková M. Hořejší J. De Rijck Z. Debyser K. Adelman H. C. Hodges V. Veverka

Science 374 (6571): 1113-1121 (2021)

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Identification of specific carbonic anhydrase inhibitors via in situ click chemistry, phage-display and synthetic peptide libraries: comparison of the methods and structural study

M. Kugler M. Hadzima R. Dzijak R. Rampmaier P. Srb L. Vrzal Z. Voburka P. Majer P. Řezáčová M. Vrábel

RSC Medicinal Chemistry 1 (14): 144–153 (2023)

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Molecular Mechanism of LEDGF/p75 Dimerization

V. Lux T. Brouns K. Čermáková P. Srb M. Fábry M. Mádlíková M. Hořejší Z. Kukačka P. Novák M. Kugler J. Brynda J. DeRijck F. Christ Z. Debyser V. Veverka

Structure 28 (12): 1288-1299 (2020)

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