IOCB Prague

Pavlína Maloy Řezáčová Group

Structural Biology
Research Group
Senior
BIO cluster

About our group

Our research focuses on understanding the three-dimensional structures of proteins and how they interact with other proteins and DNA. By studying these structures, we aim to reveal how proteins function at a molecular level and how this knowledge can be used to develop new drugs.

One key area of our work is bacterial transcription regulators. We investigate how these proteins bind to DNA, how they assemble into functional complexes, and how they control gene expression. To do this, we use techniques like X-ray crystallography and biophysical analysis to determine their structures and mechanisms of action.

Another major focus is structure-based drug design, which we carry out in close collaboration with medicinal chemists. We work on developing inhibitors for human enzymes linked to diseases, including carbonic anhydrases, kinases, purine nucleoside phosphorylases, and purine nucleotidases.

Additionally, we develop methods for macromolecular crystallization, improving techniques for collecting structural data at room temperature and screening small molecules that bind to proteins. Our interdisciplinary research, combining structural biology, biophysics, and medicinal chemistry, helps to uncover the molecular basis of protein function and guide the discovery of new therapeutic strategies

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Publications

All publications
CDK2-based CDK7 mimic as a tool for structural analysis: Biochemical validation and crystal structure with SY5609
International Journal of Biological Macromolecules 294: 139117 (2025)
Structural characterization of two prototypical repressors of SorC family reveals tetrameric assemblies on DNA and mechanism of function
Nucleic Acids Research 52 (12): 7305–7320 (2024)
Structure and function of bacterial transcription regulators of the SorC family
Transcription 15 (3–5): 139-160 (2024)
Crystal structure of blue laccase BP76, a unique termite suicidal defense weapon
Structure 32 (10): 1581-1585.e5 (2024)