About our group
Our mission is to identify and validate key biological interactions implicated in human pathologies that could be targeted in therapeutic intervention. With this goal in mind we focus on detailed understanding of molecular mechanisms of various biological processes using the means of integrative structural biology. We use structural knowledge for understanding and also modulation of biological roles of proteins and protein-protein complexes. We foster our own research projects and actively share our expertise through a number of collaborations with the scientific community mainly but not exclusively at IOCB.
Publications
All publications
Structural characterization of two prototypical repressors of SorC family reveals tetrameric assemblies on DNA and mechanism of function
Nucleic Acids Research 52 (12): 7305–7320 (2024)
Structure and function of bacterial transcription regulators of the SorC family
Transcription 2024: Early View
Crystal structure of blue laccase BP76, a unique termite suicidal defense weapon
Structure 32 (10): 1581-1585.e5 (2024)
Design, Synthesis, Biological Evaluation, and Crystallographic Study of Novel Purine Nucleoside Phosphorylase Inhibitors
Journal of Medicinal Chemistry 66 (10): 6652–6681 (2023)
Inhibitors of CA IX Enzyme Based on Polyhedral Boron Compounds
ChemBioChem 22 (18): 2741-2761 (2021)
Rutinosidase from Aspergillus niger: crystal structure and insight into the enzymatic activity
FEBS Journal 587 (15): 3315-3327 (2020)
